Evolution of Marginal Zone Lymphoma Towards Myeloproliferative Disorder: A Case Report
نویسندگان
چکیده
Introduction Lymphoma is a hematologic malignancy characterized by nodal or extranodal malignant infiltration by monoclonal lymphoid cells (B lineage cells in 70% of the cases). Its etiology is not precisely known. Prolonged life expectancy has resulted in increase of the disease incidence. Marginal zone lymphoma is a low-grade small B-cell lymphoma incorporated in the World Health Organization classification. Low-grade lymphomas usually demonstrate a characteristic natural history with multiple remissions and relapses. Myeloproliferative syndromes (MPS) are characterized by clonal proliferation of one or more hematopoietic progenitor cell lines such as granulocytes, erythrocytes, megakaryocytes, or mastocytes. These syndromes include chronic myeloid leukemia, polycythemia vera, essential thrombocythemia, myelofibrosis, chronic eosinophilic leukemia( hypereosinophilic syndrome), chronic neutrophilic leukemia, and systemic mastocytosis. They are thought to arise from malignant transformation of hematopoietic stem cells. Here, we present a case report of a patient followed and treated for marginal zone lymphoma that evolved to a myeloproliferative disorder.
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